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KMID : 0525720100150040228
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Journal of Chitin and Chitosan
2010 Volume.15 No. 4 p.228 ~ p.232
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Comparative Effect of Carboxymethyl cellulose, Chondroitin, and Carboxymethyl chitosan on Preventing Uterine Horn Adhesion Formation in Rats
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Jang Hwan-Soo
Park Sang-Joon
Kwak Dong-Mi
Jang Kwang-Ho
Kwon Young-Sam
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Abstract
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This study was performed to compare the effects of carboxymethyl cellulose (CMCE), chondroitin sulfate (CHON), and
carboxymethyl chitosan (CMCH) on preventing uterine horn adhesion. Adhesions were induced by suturing both the uterine serosa and peritoneum abrased until petechial bleeding occurred. Fourteen days later, adhesions were evaluated clinically and histopathologically. The tensile strength of adhesions formed significantly decreased in the CMCE and CMCH groups (p < 0.05). The distance of adhesion site was significantly increased in the CMCE and CMCH groups comparing control group (p < 0.05). In the CMCE, CHON, and CMCH groups, the inflammatory cell infiltration, collagen hyperplasia, and neovascularization were significantly lower than those of control
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KEYWORD
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carboxymethyl cellulose, chondroitin, carboxymethyl chitosan
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